A professional-grade anti-aging cream that combines three of skincare's most powerful regenerative actives — spicule, retinol, and PDRN — into a single intensive treatment. Mary&May's Spicule Retinol PDRN Cream uses micro-spicule technology to physically channel retinol and PDRN deeper into the skin than conventional topical application allows, dramatically amplifying the efficacy of both actives for visible anti-aging, resurfacing, and regenerative results.

Key Benefits

• Micro-Spicule Delivery Technology — Natural silica micro-spicules create micro-channels in the skin's surface, bypassing the stratum corneum barrier to deliver retinol and PDRN at significantly greater depths than standard topical creams — resulting in faster, more visible results with lower active concentrations.
• Retinol Anti-Aging & Resurfacing — Retinol accelerates cell turnover, stimulates collagen synthesis, and visibly reduces fine lines, wrinkles, and uneven skin texture. Delivered deeper via spicule technology, its resurfacing and firming effects are amplified compared to conventional retinol creams.
• PDRN Regeneration & Repair — PDRN stimulates the skin's natural regenerative processes at the cellular level, accelerating tissue repair, promoting collagen and elastin production, and restoring skin vitality and resilience alongside retinol's resurfacing action.
• Visibly Firms & Smooths — The combined action of spicule-delivered retinol and PDRN visibly firms sagging skin, smooths rough texture, and refines enlarged pores for a more youthful, polished complexion.
• Intensive Treatment in a 15g Format — Concentrated professional-grade formula in a trial or travel-friendly 15g size, ideal for introducing the spicule treatment into your routine or for use during travel.

How to Use

Apply a small amount to the face in the evening after toner and serum, avoiding the eye area. Gently press into the skin until absorbed. A mild tingling sensation is normal and indicates the spicule delivery is active. Follow with a nourishing moisturizer. Use 2–3 times per week initially and increase frequency as tolerated. Always apply SPF the following morning. Not recommended for very sensitive or compromised skin without patch testing first.

Key Ingredients

• Micro-Spicule — physical micro-channeling for deeper active delivery
• Retinol — cell turnover acceleration, collagen synthesis, and fine line reduction
• PDRN — cellular regeneration, tissue repair, and elasticity restoration
• Niacinamide — brightening and barrier-strengthening

Product Details

• Volume: 15g
• Skin Type: Normal to resilient skin; patch test recommended for sensitive skin
• Brand: Mary&May
• Origin: Korea